Prozac with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Prozac (Fluoxetine). Most antibiotics do not interfere meaningfully with Fluoxetine at 10mg, 20mg, 40mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Anti-Depressants agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Fluoxetine at 10mg, 20mg, 40mg.
Practical guidance
According to the prescribing information for Fluoxetine, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Prozac is co-administered. Adjusted 10mg, 20mg, 40mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Prozac during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Fluoxetine is metabolised and may need a temporary 10mg, 20mg, 40mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Prozac regimen.
Will antibiotics make Prozac stop working? ▾
Most antibiotics do not affect Prozac efficacy. Rifampicin and a few others can lower Fluoxetine levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
More on Prozac
- With alcoholProzac and alcohol — is it safe to drink?
- With foodShould Prozac be taken with food?
- Side effectsProzac side effects: common, rare and warning signs
- Dosage guideProzac dosage guide: how much to take and when
- OnsetHow fast does Prozac start working?
- DurationHow long does Prozac last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.