Who should not take Prilosec
A contraindication is a condition under which Prilosec (Omeprazole) should not be taken because the risk outweighs the benefit. Prilosec has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 10mg, 20mg, 40mg dosing range.
Absolute contraindications
According to the prescribing information for Omeprazole, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Prilosec can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Omeprazole is a substituted benzimidazole prodrug activated in the acidic environment of the gastric parietal cell, where it irreversibly inhibits the H+/K+-ATPase enzyme — the proton pump responsible…
Frequently asked questions
Can someone with heart disease take Prilosec? ▾
Some forms of heart disease are absolute contraindications for Prilosec, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Prilosec use under specialist supervision. The prescribing information for Omeprazole should be reviewed.
Is Prilosec safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Prilosec at adjusted lower 10mg, 20mg, 40mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
More on Prilosec
- With alcoholPrilosec and alcohol — is it safe to drink?
- With foodShould Prilosec be taken with food?
- Side effectsPrilosec side effects: common, rare and warning signs
- Dosage guidePrilosec dosage guide: how much to take and when
- OnsetHow fast does Prilosec start working?
- DurationHow long does Prilosec last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.