Plan B with statins (atorvastatin, rosuvastatin, simvastatin)
Statins are among the most widely prescribed chronic medications, often used alongside many other agents including Plan B (Levonorgestrel). The combination at 1.5mg is generally safe, but a small number of statin-specific interactions matter — particularly for simvastatin, which shares CYP3A4 metabolism with several common medications.
How Plan B interacts with statins
Statins differ in their metabolic pathways: simvastatin and atorvastatin go through CYP3A4 most heavily; rosuvastatin and pravastatin take other routes and have fewer drug interactions. If Levonorgestrel acts on CYP3A4, the combination with simvastatin or atorvastatin can raise statin levels and increase muscle-related side effects. Plan B's primary mechanism is delaying or preventing ovulation when taken before the LH surge.
Practical guidance
According to the prescribing information for Levonorgestrel, anyone on a statin should mention it before starting Plan B at 1.5mg. The prescriber may switch the statin (e.g. from simvastatin to rosuvastatin) or adjust the statin dose during Plan B use. Persistent muscle pain, weakness or dark urine on the combination warrants prompt evaluation.
Frequently asked questions
Can I take Plan B with my statin? ▾
For most users at 1.5mg, yes — particularly with rosuvastatin or pravastatin which have minimal interactions with Levonorgestrel. Simvastatin and atorvastatin combinations may need a dose review by the prescriber to avoid amplified statin effects.
Will Plan B cause muscle pain with my statin? ▾
Muscle pain is the most common statin side effect and can be amplified when combined with medications that raise statin plasma levels. Persistent or new muscle pain on Plan B at 1.5mg should be reported promptly so the prescriber can review the combination.
More on Plan B
- With alcoholPlan B and alcohol — is it safe to drink?
- With foodShould Plan B be taken with food?
- Side effectsPlan B side effects: common, rare and warning signs
- Dosage guidePlan B dosage guide: how much to take and when
- OnsetHow fast does Plan B start working?
- DurationHow long does Plan B last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.