Microzide with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Microzide (Hydrochlorothiazide). Most antibiotics do not interfere meaningfully with Hydrochlorothiazide at 12.5mg, 25mg, 50mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Diuretics agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Hydrochlorothiazide at 12.5mg, 25mg, 50mg.
Practical guidance
According to the prescribing information for Hydrochlorothiazide, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Microzide is co-administered. Adjusted 12.5mg, 25mg, 50mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Microzide during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Hydrochlorothiazide is metabolised and may need a temporary 12.5mg, 25mg, 50mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Microzide regimen.
Will antibiotics make Microzide stop working? ▾
Most antibiotics do not affect Microzide efficacy. Rifampicin and a few others can lower Hydrochlorothiazide levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
More on Microzide
- With alcoholMicrozide and alcohol — is it safe to drink?
- With foodShould Microzide be taken with food?
- Side effectsMicrozide side effects: common, rare and warning signs
- Dosage guideMicrozide dosage guide: how much to take and when
- OnsetHow fast does Microzide start working?
- DurationHow long does Microzide last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.