How to take Lexapro tablets correctly
How a tablet is swallowed matters for absorption, gastric tolerance and avoiding oesophageal irritation. Lexapro (Escitalopram) at 5mg, 10mg, 20mg is straightforward to take for most adults but a few practical points reduce variability and minimise local side effects.
Standard administration of Lexapro
Most tablet of Escitalopram are taken whole with a full glass of water (about 200 mL). Sitting or standing upright for 10–15 minutes after dosing reduces the risk of the tablet lodging in the oesophagus and causing local irritation. Sufficient water carries the medication into the stomach where dissolution and absorption begin.
Practical tips and what to avoid
According to the prescribing information for Escitalopram, taking Lexapro with too little water or while lying down increases oesophageal exposure and can cause heartburn-like irritation in susceptible users. Lukewarm or cool water is preferable to very hot water. Tablets should not be chewed unless explicitly authorised by the prescriber for the formulation; Lexapro acts by selectively inhibiting the serotonin reuptake transporter (SERT) at the synapse, increasing serotonin availability for postsynaptic receptors.
Frequently asked questions
How much water should I take with Lexapro? ▾
A full glass — about 200 mL — is the standard recommendation for Lexapro at 5mg, 10mg, 20mg. Less water increases the risk of the tablet sticking on the way down and causing local irritation.
Can I take Lexapro without water? ▾
It is not advisable. Tablets without water can lodge in the oesophagus and cause local irritation; some formulations require water for proper dissolution. Always take Lexapro with adequate water unless the formulation explicitly says otherwise.
More on Lexapro
- With alcoholLexapro and alcohol — is it safe to drink?
- With foodShould Lexapro be taken with food?
- Side effectsLexapro side effects: common, rare and warning signs
- Dosage guideLexapro dosage guide: how much to take and when
- OnsetHow fast does Lexapro start working?
- DurationHow long does Lexapro last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.