Desyrel and cannabis (marijuana, THC)
As cannabis becomes legal or decriminalised in more jurisdictions, the practical question of combining it with prescription medication comes up regularly. Desyrel (Trazodone) and cannabis share several pharmacological pathways, and the combination at 50mg, 100mg, 150mg, 300mg is not automatically benign even where both are legal.
How cannabis affects Desyrel
THC and other cannabinoids are metabolised partly by hepatic CYP enzymes, including CYP3A4 — the same pathway used by many Anti-Depressants medications. Frequent cannabis use can shift the metabolism of Trazodone mildly. THC also has cardiovascular effects (increased heart rate, blood pressure changes) and central nervous system effects that can stack with Desyrel's side-effect profile.
Practical guidance
Occasional moderate cannabis use is unlikely to cause clinically meaningful problems for most adults on Desyrel at 50mg, 100mg, 150mg, 300mg. Heavy daily use, edibles with high THC content, or cannabis combined with alcohol substantially raise the risk of dizziness, hypotension, impaired judgement and amplified side effects from Trazodone. According to the prescribing information, the full list of recreational substances should be disclosed to the prescriber.
Frequently asked questions
Can I use cannabis while taking Desyrel? ▾
For most adults at 50mg, 100mg, 150mg, 300mg, occasional moderate cannabis is tolerated, but heavy daily use is not advised because of metabolic and additive cardiovascular effects with Trazodone. The safe practice is to mention it to the prescriber.
Does CBD interact with Desyrel? ▾
CBD inhibits several CYP enzymes including CYP3A4, which can raise plasma levels of medications that go through that pathway. For Desyrel specifically, this depends on whether Trazodone uses CYP3A4. Daily high-dose CBD products warrant a pharmacist check.
More on Desyrel
- With alcoholDesyrel and alcohol — is it safe to drink?
- With foodShould Desyrel be taken with food?
- Side effectsDesyrel side effects: common, rare and warning signs
- Dosage guideDesyrel dosage guide: how much to take and when
- OnsetHow fast does Desyrel start working?
- DurationHow long does Desyrel last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.