Skin side effects of Desyrel: rash, dryness, photosensitivity
Skin reactions are among the most visible side effects of medication and range from minor cosmetic concerns to medical emergencies. Desyrel (Trazodone) at 50mg, 100mg, 150mg, 300mg may produce a range of skin effects depending on Trazodone; this page covers what is typical, what is rare, and what calls for stopping the medication.
Common skin effects of Desyrel
According to the prescribing information for Trazodone, common skin reactions include mild rash, dryness, mild itching, transient flushing and (for some agents) photosensitivity that makes the skin more sensitive to UV. Trazodone is classified as a serotonin antagonist and reuptake inhibitor (SARI). Most are mild, appear in the first weeks and resolve without intervention or with simple measures (moisturiser, sunscreen).
Serious skin reactions
Severe skin reactions — Stevens-Johnson syndrome, toxic epidermal necrolysis, drug-induced hypersensitivity syndrome — are rare but life-threatening. Warning signs are a rash with fever, mucosal involvement (mouth, eyes), skin peeling, or rapidly spreading rash. Any of these on Desyrel at 50mg, 100mg, 150mg, 300mg is a medical emergency and reason to stop the medication and seek immediate care.
Frequently asked questions
Is a rash on Desyrel dangerous? ▾
Most rashes on Desyrel at 50mg, 100mg, 150mg, 300mg are mild and resolve. A rash with fever, mucosal involvement, blistering or rapid spread is not — it requires emergency evaluation and stopping the medication.
Can Desyrel cause sunburn or photosensitivity? ▾
Some medications including a subset of Anti-Depressants agents increase UV sensitivity, making sunburn occur faster. The prescribing information for Trazodone lists this when documented. Sunscreen and avoiding peak sun exposure manage the risk.
More on Desyrel
- With alcoholDesyrel and alcohol — is it safe to drink?
- With foodShould Desyrel be taken with food?
- Side effectsDesyrel side effects: common, rare and warning signs
- Dosage guideDesyrel dosage guide: how much to take and when
- OnsetHow fast does Desyrel start working?
- DurationHow long does Desyrel last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.