Who should not take Celebrex
A contraindication is a condition under which Celebrex (Celecoxib) should not be taken because the risk outweighs the benefit. Celebrex has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 50mg, 100mg, 200mg, 400mg dosing range.
Absolute contraindications
According to the prescribing information for Celecoxib, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Celebrex can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Celecoxib selectively inhibits COX-2, the inducible isoform of cyclooxygenase upregulated at sites of inflammation, while sparing the constitutive COX-1 that maintains gastric mucosal integrity and pl…
Frequently asked questions
Can someone with heart disease take Celebrex? ▾
Some forms of heart disease are absolute contraindications for Celebrex, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Celebrex use under specialist supervision. The prescribing information for Celecoxib should be reviewed.
Is Celebrex safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Celebrex at adjusted lower 50mg, 100mg, 200mg, 400mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
More on Celebrex
- With alcoholCelebrex and alcohol — is it safe to drink?
- With foodShould Celebrex be taken with food?
- Side effectsCelebrex side effects: common, rare and warning signs
- Dosage guideCelebrex dosage guide: how much to take and when
- OnsetHow fast does Celebrex start working?
- DurationHow long does Celebrex last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.