Caverject with the birth control pill
Many women of reproductive age take a combined or progestogen-only oral contraceptive while also using a chronic medication such as Caverject (Alprostadil). The combination is generally fine at 10mcg, 20mcg, 40mcg, but a small number of medications can reduce contraceptive efficacy meaningfully and need either a backup method or a switch.
How Caverject can affect contraceptive efficacy
Combined and progestogen-only contraceptives are metabolised through CYP3A4. Strong CYP3A4 inducers (some antiepileptics, rifampicin, St John's Wort) lower contraceptive plasma levels and reduce efficacy. Whether Alprostadil acts on CYP3A4 determines whether Caverject affects contraception. Most agents in Erectile Dysfunction (ED) have no clinically meaningful effect on the pill at 10mcg, 20mcg, 40mcg.
Practical guidance
According to the prescribing information for Alprostadil, women on hormonal contraception should review Caverject with the prescribing pharmacist or doctor. Where an interaction is documented, additional barrier contraception or switching to a non-oral method (IUD, implant) for the duration of Caverject therapy is the standard mitigation.
Frequently asked questions
Will Caverject make my pill less effective? ▾
Most Erectile Dysfunction (ED) medications at 10mcg, 20mcg, 40mcg do not affect oral contraceptive efficacy. The exceptions are CYP3A4-inducing drugs and a small number of others. The prescribing information for Alprostadil states whether the interaction is meaningful.
Do I need a backup contraceptive on Caverject? ▾
Backup contraception is needed only when there is a documented interaction between Caverject and the contraceptive method. For most users at 10mcg, 20mcg, 40mcg, no backup is required. The pharmacist confirms whether Alprostadil interacts with hormonal contraception.
More on Caverject
- With alcoholCaverject and alcohol — is it safe to drink?
- With foodShould Caverject be taken with food?
- Side effectsCaverject side effects: common, rare and warning signs
- Dosage guideCaverject dosage guide: how much to take and when
- OnsetHow fast does Caverject start working?
- DurationHow long does Caverject last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.