Who should not take Caverject
A contraindication is a condition under which Caverject (Alprostadil) should not be taken because the risk outweighs the benefit. Caverject has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 10mcg, 20mcg, 40mcg dosing range.
Absolute contraindications
According to the prescribing information for Alprostadil, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Caverject can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Alprostadil binds prostaglandin E receptors on smooth muscle of the corpus cavernosum, triggering cAMP-mediated relaxation of cavernosal smooth muscle independent of the nitric oxide pathway used by P…
Frequently asked questions
Can someone with heart disease take Caverject? ▾
Some forms of heart disease are absolute contraindications for Caverject, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Caverject use under specialist supervision. The prescribing information for Alprostadil should be reviewed.
Is Caverject safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Caverject at adjusted lower 10mcg, 20mcg, 40mcg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
More on Caverject
- With alcoholCaverject and alcohol — is it safe to drink?
- With foodShould Caverject be taken with food?
- Side effectsCaverject side effects: common, rare and warning signs
- Dosage guideCaverject dosage guide: how much to take and when
- OnsetHow fast does Caverject start working?
- DurationHow long does Caverject last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.