Wellbutrin vs Lexapro: side-by-side comparison
Wellbutrin (Bupropion) and Lexapro (Escitalopram) both belong to the Anti-Depressants class. They share clinical context but use different active ingredients. The choice between them depends on mechanism nuances, side-effect profile and individual response.
| Property | Wellbutrin | Lexapro |
|---|---|---|
| Active ingredient | Bupropion | Escitalopram |
| Manufacturer | GlaxoSmithKline | Forest/Allergan |
| Class | Anti-Depressants | Anti-Depressants |
| Strengths | 75mg, 100mg, 150mg, 300mg | 5mg, 10mg, 20mg |
| Forms | tablet | tablet |
What's the same
Wellbutrin and Lexapro both belong to the Anti-Depressants class and are used for partially overlapping indications. The active ingredients — Bupropion vs Escitalopram — share the same therapeutic approach, so many safety and management points carry across both.
Key differences
Meaningful differences are in active ingredient (Bupropion vs Escitalopram), strengths (75mg, 100mg, 150mg, 300mg vs 5mg, 10mg, 20mg), forms (tablet vs tablet), and the mechanism, half-life and side-effect nuances that distinguish members of the class.
Mechanism and action
Wellbutrin: Wellbutrin inhibits the reuptake of norepinephrine and dopamine, with much weaker effect on serotonin. Lexapro: Lexapro acts by selectively inhibiting the serotonin reuptake transporter (SERT) at the synapse, increasing serotonin availability for postsynaptic receptors.
When Wellbutrin is preferred
Wellbutrin is approved for major depressive disorder and prevention of seasonal affective disorder recurrence (Wellbutrin XL).
When Lexapro is preferred
Lexapro is approved for major depressive disorder and generalised anxiety disorder in adults and adolescents 12 years and older (depression) and adults (generalised anxiety).
Frequently asked questions
Is Wellbutrin or Lexapro better? ▾
There is no single answer. Wellbutrin and Lexapro both belong to the Anti-Depressants class but differ in mechanism nuances, half-life and side-effect profile. Preference depends on the patient, the prescriber and prior response to other therapies.
Can I switch from Wellbutrin to Lexapro? ▾
Switching within the Anti-Depressants class is done under supervision, typically using equivalent doses and a follow-up period to confirm response and tolerance. It is not a self-directed decision.
Do Wellbutrin and Lexapro have the same side effects? ▾
They share many of the Anti-Depressants class side effects, with differences from mechanism and dose. Each medication's prescribing information lists specifics.
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The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.