Sertraline vs Cymbalta: side-by-side comparison
Sertraline (Sertraline) and Cymbalta (Duloxetine) both belong to the Anti-Depressants class. They share clinical context but use different active ingredients. The choice between them depends on mechanism nuances, side-effect profile and individual response.
| Property | Sertraline | Cymbalta |
|---|---|---|
| Active ingredient | Sertraline | Duloxetine |
| Manufacturer | Various generics | Eli Lilly |
| Class | Anti-Depressants | Anti-Depressants |
| Strengths | 25mg, 50mg, 100mg | 20mg, 30mg, 60mg |
| Forms | tablet | capsule |
What's the same
Sertraline and Cymbalta both belong to the Anti-Depressants class and are used for partially overlapping indications. The active ingredients — Sertraline vs Duloxetine — share the same therapeutic approach, so many safety and management points carry across both.
Key differences
Meaningful differences are in active ingredient (Sertraline vs Duloxetine), strengths (25mg, 50mg, 100mg vs 20mg, 30mg, 60mg), forms (tablet vs capsule), and the mechanism, half-life and side-effect nuances that distinguish members of the class.
Mechanism and action
Sertraline: Sertraline selectively blocks the serotonin transporter on the presynaptic neuron, preventing reuptake of serotonin from the synaptic cleft. Cymbalta: Cymbalta inhibits the reuptake of both serotonin and norepinephrine at the synapse.
When Sertraline is preferred
Generic sertraline shares the indications of the originator: major depressive disorder, panic disorder, OCD, PTSD, social anxiety disorder, and premenstrual dysphoric disorder, all in adults.
When Cymbalta is preferred
Cymbalta is approved for major depressive disorder, generalised anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia and chronic musculoskeletal pain.
Frequently asked questions
Is Sertraline or Cymbalta better? ▾
There is no single answer. Sertraline and Cymbalta both belong to the Anti-Depressants class but differ in mechanism nuances, half-life and side-effect profile. Preference depends on the patient, the prescriber and prior response to other therapies.
Can I switch from Sertraline to Cymbalta? ▾
Switching within the Anti-Depressants class is done under supervision, typically using equivalent doses and a follow-up period to confirm response and tolerance. It is not a self-directed decision.
Do Sertraline and Cymbalta have the same side effects? ▾
They share many of the Anti-Depressants class side effects, with differences from mechanism and dose. Each medication's prescribing information lists specifics.
More Sertraline comparisons
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.