Provera vs Evista: side-by-side comparison
Provera (Women's Sexual Health) and Evista (Hormones and Birth Control) belong to different therapeutic classes and are rarely interchangeable. This page compares the medications' purposes, mechanisms and the situations where each is used.
| Property | Provera | Evista |
|---|---|---|
| Active ingredient | Medroxyprogesterone | Raloxifene |
| Manufacturer | Pfizer | Eli Lilly |
| Class | Women's Sexual Health | Hormones and Birth Control |
| Strengths | 2.5mg, 5mg, 10mg | 60mg |
| Forms | tablet | tablet |
What's the same
Provera and Evista are used in very different patients, and the points in common are limited. The main shared element is that both meet regulatory standards for efficacy and safety and benefit from pharmacist oversight.
Key differences
Provera belongs to Women's Sexual Health while Evista belongs to Hormones and Birth Control. Indications, mechanisms and target populations differ. The comparison is most useful when a clinician has mentioned both medications and the patient wants to understand where each fits.
Mechanism and action
Provera: Medroxyprogesterone acetate binds progesterone receptors and produces strong progestational effects: thickening cervical mucus, inhibiting ovulation, thinning the endometrium and reducing endometrial proliferation in HRT… Evista: Raloxifene binds estrogen receptors and produces tissue-selective effects: estrogen-agonist activity in bone (preserving bone mineral density) and on lipid metabolism (lowering LDL cholesterol), while exhibiting estrogen…
When Provera is preferred
Provera is approved for amenorrhoea, abnormal uterine bleeding due to hormonal imbalance, and prevention of endometrial hyperplasia in postmenopausal women receiving estrogen.
When Evista is preferred
Evista is approved for prevention and treatment of postmenopausal osteoporosis and for reduction of invasive breast cancer risk in postmenopausal women at increased risk.
Frequently asked questions
Is Provera or Evista better? ▾
Provera and Evista are not interchangeable — they treat different conditions. Asking which is "better" is meaningful only when a clinician has weighed both for the same specific clinical scenario.
Can I switch from Provera to Evista? ▾
Switching between Provera and Evista is rarely an appropriate decision since they belong to different classes and treat different conditions. The real question is usually whether the diagnosis calls for one medication or the other — which the prescriber resolves.
Do Provera and Evista have the same side effects? ▾
No — they belong to different classes and have distinct side-effect profiles. Each medication has its own prescribing information.
More Provera comparisons
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.