Paxil vs Sertraline: side-by-side comparison
Paxil (Paroxetine) and Sertraline (Sertraline) both belong to the Anti-Depressants class. They share clinical context but use different active ingredients. The choice between them depends on mechanism nuances, side-effect profile and individual response.
| Property | Paxil | Sertraline |
|---|---|---|
| Active ingredient | Paroxetine | Sertraline |
| Manufacturer | GlaxoSmithKline | Various generics |
| Class | Anti-Depressants | Anti-Depressants |
| Strengths | 10mg, 20mg, 30mg, 40mg | 25mg, 50mg, 100mg |
| Forms | tablet | tablet |
What's the same
Paxil and Sertraline both belong to the Anti-Depressants class and are used for partially overlapping indications. The active ingredients — Paroxetine vs Sertraline — share the same therapeutic approach, so many safety and management points carry across both.
Key differences
Meaningful differences are in active ingredient (Paroxetine vs Sertraline), strengths (10mg, 20mg, 30mg, 40mg vs 25mg, 50mg, 100mg), forms (tablet vs tablet), and the mechanism, half-life and side-effect nuances that distinguish members of the class.
Mechanism and action
Paxil: Paroxetine selectively inhibits the serotonin reuptake transporter (SERT), increasing synaptic serotonin availability. Sertraline: Sertraline selectively blocks the serotonin transporter on the presynaptic neuron, preventing reuptake of serotonin from the synaptic cleft.
When Paxil is preferred
Paxil is approved for major depressive disorder, generalised anxiety disorder, social anxiety disorder, panic disorder, obsessive-compulsive disorder and post-traumatic stress disorder, with regional variation.
When Sertraline is preferred
Generic sertraline shares the indications of the originator: major depressive disorder, panic disorder, OCD, PTSD, social anxiety disorder, and premenstrual dysphoric disorder, all in adults.
Frequently asked questions
Is Paxil or Sertraline better? ▾
There is no single answer. Paxil and Sertraline both belong to the Anti-Depressants class but differ in mechanism nuances, half-life and side-effect profile. Preference depends on the patient, the prescriber and prior response to other therapies.
Can I switch from Paxil to Sertraline? ▾
Switching within the Anti-Depressants class is done under supervision, typically using equivalent doses and a follow-up period to confirm response and tolerance. It is not a self-directed decision.
Do Paxil and Sertraline have the same side effects? ▾
They share many of the Anti-Depressants class side effects, with differences from mechanism and dose. Each medication's prescribing information lists specifics.
More Paxil comparisons
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.