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Lyrica vs Viagra Professional: side-by-side comparison

Lyrica (Pregabalin) 25mg capsule
Lyrica
vs
Viagra Professional (Sildenafil Citrate) 100mg sublingual tablet
Viagra Professional

Lyrica (Pain Relief Medications) and Viagra Professional (Erectile Dysfunction (ED)) belong to different therapeutic classes and are rarely interchangeable. This page compares the medications' purposes, mechanisms and the situations where each is used.

Property Lyrica Viagra Professional
Active ingredient Pregabalin Sildenafil Citrate
Manufacturer Pfizer Pfizer
Class Pain Relief Medications Erectile Dysfunction (ED)
Strengths 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, 300mg 100mg
Forms capsule, oral solution, extended-release tablet sublingual tablet

What's the same

Lyrica and Viagra Professional are used in very different patients, and the points in common are limited. The main shared element is that both meet regulatory standards for efficacy and safety and benefit from pharmacist oversight.

Key differences

Lyrica belongs to Pain Relief Medications while Viagra Professional belongs to Erectile Dysfunction (ED). Indications, mechanisms and target populations differ. The comparison is most useful when a clinician has mentioned both medications and the patient wants to understand where each fits.

Mechanism and action

Lyrica: Pregabalin binds the alpha-2-delta auxiliary subunit of voltage-gated calcium channels in the central nervous system, reducing presynaptic calcium influx and the release of excitatory neurotransmitters such as glutamate… Viagra Professional: Sildenafil citrate inhibits PDE5, allowing the cyclic GMP produced during sexual arousal to accumulate in penile tissue, which relaxes the smooth muscle of the penile arteries and increases blood inflow.

When Lyrica is preferred

Lyrica is approved in adults for neuropathic pain associated with diabetic peripheral neuropathy, post-herpetic neuralgia, spinal cord injury and other forms of central neuropathic pain (some markets), for generalised anxiety disorder, for fibromyalgia (in the United States and s…

When Viagra Professional is preferred

Viagra Professional is intended for adult men with erectile dysfunction.

Frequently asked questions

Is Lyrica or Viagra Professional better?

Lyrica and Viagra Professional are not interchangeable — they treat different conditions. Asking which is "better" is meaningful only when a clinician has weighed both for the same specific clinical scenario.

Can I switch from Lyrica to Viagra Professional?

Switching between Lyrica and Viagra Professional is rarely an appropriate decision since they belong to different classes and treat different conditions. The real question is usually whether the diagnosis calls for one medication or the other — which the prescriber resolves.

Do Lyrica and Viagra Professional have the same side effects?

No — they belong to different classes and have distinct side-effect profiles. Each medication has its own prescribing information.

More Lyrica comparisons

The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.