Lexapro vs Citalopram: brand vs ingredient
Lexapro contains Escitalopram, while Citalopram is a different active ingredient in the Selective serotonin reuptake inhibitor (SSRI) class. This page compares them: when each is used, how the mechanisms and indications differ, and whether the question "Lexapro vs Citalopram" makes sense to ask at all.
What is the relationship?
Lexapro and Citalopram are different things: Lexapro is a branded medication whose active ingredient is Escitalopram (in the Anti-Depressants class), whereas Citalopram is in the Selective serotonin reuptake inhibitor (SSRI) class. They share a common therapeutic context and are sometimes weighed in the same clinical decision.
When Lexapro is used
Lexapro is approved for major depressive disorder and generalised anxiety disorder in adults and adolescents 12 years and older (depression) and adults (generalised anxiety).
When Citalopram is used
Citalopram is approved for major depressive disorder.
Mechanisms compared
Lexapro: Lexapro acts by selectively inhibiting the serotonin reuptake transporter (SERT) at the synapse, increasing serotonin availability for postsynaptic receptors. Citalopram: Citalopram selectively inhibits the serotonin reuptake transporter, increasing synaptic serotonin availability with limited affinity for noradrenaline transporters or other receptors.
When the comparison makes sense
Comparing Lexapro with Citalopram makes sense when both are in the same clinical decision: they belong to the same therapeutic class and may be considered as alternatives. If the question is between two options for the same need, the prescriber decides based on prior response, comorbidities and tolerance.
Frequently asked questions
Do Lexapro and Citalopram treat the same thing? ▾
They treat partially overlapping conditions, both in the Anti-Depressants area. The question of which to use is for the prescriber to answer based on the specific indication.
Can Lexapro and Citalopram be combined? ▾
It depends on the interaction profile of Escitalopram with Citalopram. If both are in a single prescription, the prescriber has weighed it. Self-medicating with both is not recommended without pharmacist review.
Which is better, Lexapro or Citalopram? ▾
"Better" doesn't apply between medications for different indications. The sensible question is which fits your specific clinical need — that is the prescriber's call.
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.