Trazodone vs Flibanserin: side-by-side comparison
Trazodone (Atypical antidepressant / serotonin modulator) and Flibanserin (Multifunctional serotonin agonist/antagonist (HSDD)) belong to different therapeutic classes and are rarely substitutes for each other. The comparison is useful when a single patient is weighing both options for adjacent or overlapping needs.
| Property | Trazodone | Flibanserin |
|---|---|---|
| Therapeutic class | Atypical antidepressant / serotonin modulator | Multifunctional serotonin agonist/antagonist (HSDD) |
| CAS | 19794-93-5 | 167933-07-5 |
| ATC | N06AX05 | G02CX02 |
| Molecular weight | 371.86 g/mol | 390.4 g/mol |
| Brands with this active ingredient | 1 | 1 |
What they share
Trazodone and Flibanserin share the common regulatory framework for prescription active ingredients, bioequivalence standards for generics, and pharmacist oversight. Beyond that, points in common are limited.
Key differences
Trazodone acts by a different mechanism than Flibanserin, with indications that barely overlap. Comparing the two is useful when a clinician has mentioned both in the same context or the patient wants to understand why one was prescribed instead of the other.
Mechanisms compared
Trazodone: Trazodone is classified as a serotonin antagonist and reuptake inhibitor (SARI). Flibanserin: Flibanserin acts as a serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist, with additional effects on dopamine and norepinephrine signalling.
Indications compared
Trazodone: Trazodone is approved for major depressive disorder. Flibanserin: Flibanserin is approved by the FDA for hypoactive sexual desire disorder (HSDD) in premenopausal women — specifically, acquired (not lifelong) and generalised (not situational) HSDD, with personal distress, not better ex…
Safety profile
Trazodone: Common adverse effects are sedation (the desired effect at low doses), dry mouth, dizziness, orthostatic hypotension and headache. Flibanserin: Common adverse effects include dizziness, somnolence, nausea, fatigue and dry mouth.
Frequently asked questions
Is Trazodone better than Flibanserin? ▾
Trazodone and Flibanserin are not "better or worse" — they treat different things. The sensible question is which fits your specific need.
Can Trazodone and Flibanserin be combined? ▾
Whether they can be combined depends on the indications and the interaction profile of each. If both are in a single prescription, the prescriber has weighed it; in self-medication they should never be combined.
Do they have the same side-effect profile? ▾
No — they belong to different classes and have distinct side-effect profiles. Each has its own prescribing information.
Products with Trazodone
Products with Flibanserin
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.