Voltaren vs Lyrica: side-by-side comparison
Voltaren (Diclofenac) and Lyrica (Pregabalin) both belong to the Schmerzmedikamente class. They share clinical context but use different active ingredients. The choice between them depends on mechanism nuances, side-effect profile and individual response.
| Property | Voltaren | Lyrica |
|---|---|---|
| Active ingredient | Diclofenac | Pregabalin |
| Manufacturer | Novartis | Pfizer |
| Class | Schmerzmedikamente | Schmerzmedikamente |
| Strengths | 25mg, 50mg, 75mg, 100mg | 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, 300mg |
| Forms | tablet, delayed-release tablet, topical gel, suppository | capsule, oral solution, extended-release tablet |
What's the same
Voltaren and Lyrica both belong to the Schmerzmedikamente class and are used for partially overlapping indications. The active ingredients — Diclofenac vs Pregabalin — share the same therapeutic approach, so many safety and management points carry across both.
Key differences
Meaningful differences are in active ingredient (Diclofenac vs Pregabalin), strengths (25mg, 50mg, 75mg, 100mg vs 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, 300mg), forms (tablet, delayed-release tablet, topical gel, suppository vs capsule, oral solution, extended-release tablet), and the mechanism, half-life and side-effect nuances that distinguish members of the class.
Mechanism and action
Voltaren: Diclofenac hemmt reversibel die Cyclooxygenase-Enzyme COX-1 und COX-2, mit etwas stärkerer Selektivität für COX-2 als Ibuprofen und Naproxen. Lyrica: Pregabalin bindet an die Alpha-2-Delta-Untereinheit spannungsabhängiger Calciumkanäle im Zentralnervensystem, wodurch der präsynaptische Calciumeinstrom und die Freisetzung exzitatorischer Neurotransmitter wie Glutamat…
When Voltaren is preferred
Voltaren ist bei Erwachsenen zur Behandlung von Arthrose, rheumatoider Arthritis, ankylosierender Spondylitis, akuten muskuloskelettalen Schmerzen, postoperativen Schmerzen, primärer Dysmenorrhoe, akuter Migräne und Ureterkolik zugelassen.
When Lyrica is preferred
Lyrica ist bei Erwachsenen zugelassen zur Behandlung neuropathischer Schmerzen bei diabetischer peripherer Neuropathie, postherpetischer Neuralgie, Rückenmarkverletzungen und anderen Formen zentraler neuropathischer Schmerzen (in einigen Ländern), zur Behandlung der generalisiert…
Häufig gestellte Fragen
Is Voltaren or Lyrica better? ▾
There is no single answer. Voltaren and Lyrica both belong to the Schmerzmedikamente class but differ in mechanism nuances, half-life and side-effect profile. Preference depends on the patient, the prescriber and prior response to other therapies.
Can I switch from Voltaren to Lyrica? ▾
Switching within the Schmerzmedikamente class is done under supervision, typically using equivalent doses and a follow-up period to confirm response and tolerance. It is not a self-directed decision.
Do Voltaren and Lyrica have the same side effects? ▾
They share many of the Schmerzmedikamente class side effects, with differences from mechanism and dose. Each medication's prescribing information lists specifics.
More Voltaren comparisons
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