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Cymbalta vs Voltaren: side-by-side comparison

Cymbalta (Duloxetine) 20mg capsule
Cymbalta
vs
Voltaren (Diclofenac) 25mg tablet
Voltaren

Cymbalta (Antidepressiva) and Voltaren (Schmerzmedikamente) belong to different therapeutic classes and are rarely interchangeable. This page compares the medications' purposes, mechanisms and the situations where each is used.

Property Cymbalta Voltaren
Active ingredient Duloxetine Diclofenac
Manufacturer Eli Lilly Novartis
Class Antidepressiva Schmerzmedikamente
Strengths 20mg, 30mg, 60mg 25mg, 50mg, 75mg, 100mg
Forms capsule tablet, delayed-release tablet, topical gel, suppository

What's the same

Cymbalta and Voltaren are used in very different patients, and the points in common are limited. The main shared element is that both meet regulatory standards for efficacy and safety and benefit from pharmacist oversight.

Key differences

Cymbalta belongs to Antidepressiva while Voltaren belongs to Schmerzmedikamente. Indications, mechanisms and target populations differ. The comparison is most useful when a clinician has mentioned both medications and the patient wants to understand where each fits.

Mechanism and action

Cymbalta: Cymbalta hemmt die Wiederaufnahme von Serotonin und Noradrenalin an der Synapse. Voltaren: Diclofenac hemmt reversibel die Cyclooxygenase-Enzyme COX-1 und COX-2, mit etwas stärkerer Selektivität für COX-2 als Ibuprofen und Naproxen.

When Cymbalta is preferred

Cymbalta ist zur Behandlung der Major Depression, der generalisierten Angststörung, diabetischer peripherer neuropathischer Schmerzen, Fibromyalgie und chronischer muskuloskelettaler Schmerzen zugelassen.

When Voltaren is preferred

Voltaren ist bei Erwachsenen zur Behandlung von Arthrose, rheumatoider Arthritis, ankylosierender Spondylitis, akuten muskuloskelettalen Schmerzen, postoperativen Schmerzen, primärer Dysmenorrhoe, akuter Migräne und Ureterkolik zugelassen.

Häufig gestellte Fragen

Is Cymbalta or Voltaren better?

Cymbalta and Voltaren are not interchangeable — they treat different conditions. Asking which is "better" is meaningful only when a clinician has weighed both for the same specific clinical scenario.

Can I switch from Cymbalta to Voltaren?

Switching between Cymbalta and Voltaren is rarely an appropriate decision since they belong to different classes and treat different conditions. The real question is usually whether the diagnosis calls for one medication or the other — which the prescriber resolves.

Do Cymbalta and Voltaren have the same side effects?

No — they belong to different classes and have distinct side-effect profiles. Each medication has its own prescribing information.

More Cymbalta comparisons

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