Xalatan vs Latanoprost: are they the same?
Xalatan is a commercial brand whose active ingredient is exactly Latanoprost. This page explains what that means in practice: where they differ (brand, manufacturer, price, available strengths), why they are clinically equivalent, and when the brand or an authorised generic is the better choice.
Are they the same?
Yes — Xalatan contains Latanoprost as its active ingredient. Talking about "Xalatan" in clinical terms is the same as talking about Latanoprost at the dose strengths 0.005%. The differences from the authorised generic are brand, manufacturer (Pfizer), excipients, tablet appearance and price — not the active molecule itself.
When Xalatan is used
キサラタンは慢性開放隅角緑内障または高眼圧症患者の眼圧上昇の低下に対し、成人および小児で承認されています。国際ガイドラインによれば、ラタノプロストなどのプロスタグランジン類縁体はその有効性、1日1回投与、好ましい全身安全性プロファイルから、新規診断された緑内障の通常第一選択療法です。単剤療法で目標眼圧に到達しない場合、他剤との併用が検討されます。
Mechanisms compared
Because they share the same active ingredient, the mechanism is identical: ラタノプロストは角膜エステラーゼにより活性遊離酸に加水分解されるプロドラッグエステルで、この遊離酸がプロスタグランジンF(FP)受容体に選択的に結合します。ぶどう膜強膜組織のFP受容体活性化はこの非繊維柱帯経路による房水流出を増加させ、眼圧を低下させます。眼圧低下効果は3~4時間以内に開始し、8~12時間でピークに達し、少なくとも24時間持続します。
Brand or generic — which to choose?
For most patients, authorised generics of Latanoprost are clinically equivalent substitutes for Xalatan and typically cost substantially less. The practical differences are manufacturer, excipients (rarely matters except in specific sensitivities), tablet appearance and price. The brand is preferred by some patients for personal reasons or insurance coverage; the generic is the default when cost matters.
よくある質問
Is Xalatan the same as Latanoprost? ▾
Clinically yes — Xalatan is the brand and Latanoprost is its active ingredient. At equivalent doses (0.005%) they produce the same effect. The difference is brand, manufacturer (Pfizer) and price.
Is generic Latanoprost as effective as Xalatan? ▾
Yes. Authorised generics of Latanoprost must demonstrate bioequivalence to the brand. The active substance is the same; average effect is the same. Price is usually substantially lower.
Why does Xalatan cost more than generic Latanoprost? ▾
The price difference reflects originator development costs, brand recognition and competition among generic manufacturers. The molecule is identical; the cost is not.
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