Provera vs Medroxyprogesterone: are they the same?
Provera is a commercial brand whose active ingredient is exactly Medroxyprogesterone. This page explains what that means in practice: where they differ (brand, manufacturer, price, available strengths), why they are clinically equivalent, and when the brand or an authorised generic is the better choice.
Are they the same?
Yes — Provera contains Medroxyprogesterone as its active ingredient. Talking about "Provera" in clinical terms is the same as talking about Medroxyprogesterone at the dose strengths 2.5mg, 5mg, 10mg. The differences from the authorised generic are brand, manufacturer (Pfizer), excipients, tablet appearance and price — not the active molecule itself.
When Provera is used
プロベラは無月経、ホルモン不均衡による異常子宮出血、エストロゲンを投与されている閉経後女性の子宮内膜増殖症予防に承認されています。現在の更年期ガイドラインによれば、乳がんおよび心血管リスクが低いことを示唆する証拠から、HRTでは一般に微粒子化プロゲステロンがMPAより好まれていますが、プロベラは依然として広く使用されており有効な代替選択肢です。
Mechanisms compared
Because they share the same active ingredient, the mechanism is identical: メドロキシプロゲステロン酢酸エステルはプロゲステロン受容体に結合し、強力な黄体作用を発揮します:子宮頸管粘液の濃稠化、排卵抑制、子宮内膜の菲薄化、HRTにおける子宮内膜増殖の減少。その弱いアンドロゲン作用および副腎皮質ステロイド作用は生体同一プロゲステロンとは異なります。HRTにおいてMPAはエストロゲン誘発性子宮内膜増殖に対抗し、子宮を有しエストロゲン投与中の女性における増殖症および子宮内膜がんを予防します。治療効果は治療開始後数日以…
Brand or generic — which to choose?
For most patients, authorised generics of Medroxyprogesterone are clinically equivalent substitutes for Provera and typically cost substantially less. The practical differences are manufacturer, excipients (rarely matters except in specific sensitivities), tablet appearance and price. The brand is preferred by some patients for personal reasons or insurance coverage; the generic is the default when cost matters.
よくある質問
Is Provera the same as Medroxyprogesterone? ▾
Clinically yes — Provera is the brand and Medroxyprogesterone is its active ingredient. At equivalent doses (2.5mg, 5mg, 10mg) they produce the same effect. The difference is brand, manufacturer (Pfizer) and price.
Is generic Medroxyprogesterone as effective as Provera? ▾
Yes. Authorised generics of Medroxyprogesterone must demonstrate bioequivalence to the brand. The active substance is the same; average effect is the same. Price is usually substantially lower.
Why does Provera cost more than generic Medroxyprogesterone? ▾
The price difference reflects originator development costs, brand recognition and competition among generic manufacturers. The molecule is identical; the cost is not.
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