Prometrium vs Progesterone: are they the same?
Prometrium is a commercial brand whose active ingredient is exactly Progesterone. This page explains what that means in practice: where they differ (brand, manufacturer, price, available strengths), why they are clinically equivalent, and when the brand or an authorised generic is the better choice.
Are they the same?
Yes — Prometrium contains Progesterone as its active ingredient. Talking about "Prometrium" in clinical terms is the same as talking about Progesterone at the dose strengths 100mg, 200mg. The differences from the authorised generic are brand, manufacturer (Catalent / Virtus), excipients, tablet appearance and price — not the active molecule itself.
When Prometrium is used
プロメトリウムはエストロゲン投与中の閉経後女性の子宮内膜保護、続発性無月経、および選択された生殖補助医療の適応症に承認されています。適応外使用には月経前不快気分障害、更年期前後の症状、選択された患者の睡眠補助が含まれます。現在の閉経ガイドラインによれば、微粉化プロゲステロンはHRTにおいて好ましいプロゲストーゲンであり、特に心血管リスク因子または片頭痛のある女性で推奨されます。
Mechanisms compared
Because they share the same active ingredient, the mechanism is identical: プロメトリウム中のプロゲステロンはプロゲステロン受容体に結合し、生殖器およびその他の組織で遺伝子発現を調節します。HRTでは、エストロゲン主導の子宮内膜増殖に対抗し、エストロゲン投与中の子宮を有する女性における過形成および子宮内膜癌を予防します。経口プロゲステロンは広範な初回通過代謝を受け、アロプレグナノロンなどのGABA作動性代謝物を生成し、特徴的な就寝時鎮静に寄与します。半減期は短い(数時間)ですが、就寝時投与は継続的な子宮内膜保護…
Brand or generic — which to choose?
For most patients, authorised generics of Progesterone are clinically equivalent substitutes for Prometrium and typically cost substantially less. The practical differences are manufacturer, excipients (rarely matters except in specific sensitivities), tablet appearance and price. The brand is preferred by some patients for personal reasons or insurance coverage; the generic is the default when cost matters.
よくある質問
Is Prometrium the same as Progesterone? ▾
Clinically yes — Prometrium is the brand and Progesterone is its active ingredient. At equivalent doses (100mg, 200mg) they produce the same effect. The difference is brand, manufacturer (Catalent / Virtus) and price.
Is generic Progesterone as effective as Prometrium? ▾
Yes. Authorised generics of Progesterone must demonstrate bioequivalence to the brand. The active substance is the same; average effect is the same. Price is usually substantially lower.
Why does Prometrium cost more than generic Progesterone? ▾
The price difference reflects originator development costs, brand recognition and competition among generic manufacturers. The molecule is identical; the cost is not.
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