Paxil vs Paroxetine: are they the same?
Paxil is a commercial brand whose active ingredient is exactly Paroxetine. This page explains what that means in practice: where they differ (brand, manufacturer, price, available strengths), why they are clinically equivalent, and when the brand or an authorised generic is the better choice.
Are they the same?
Yes — Paxil contains Paroxetine as its active ingredient. Talking about "Paxil" in clinical terms is the same as talking about Paroxetine at the dose strengths 10mg, 20mg, 30mg, 40mg. The differences from the authorised generic are brand, manufacturer (GlaxoSmithKline), excipients, tablet appearance and price — not the active molecule itself.
When Paxil is used
パキシルは地域差はあるものの、大うつ病性障害、全般性不安障害、社交不安障害、パニック障害、強迫性障害、外傷後ストレス障害の治療に承認されています。パキシルCRは月経前不快気分障害にも承認されています。妊娠中の使用は、パロキセチンが胎児の心血管奇形と関連するという証拠から一般に避けられます。
Mechanisms compared
Because they share the same active ingredient, the mechanism is identical: パロキセチンはセロトニン再取り込みトランスポーター(SERT)を選択的に阻害し、シナプスのセロトニン利用率を高めます。SERT阻害において最も強力なSSRIであり、弱い抗コリン作用を有し、治療効果(睡眠、不安)と副作用(口渇、便秘)の両方に寄与します。治療効果は4-6週間かけて構築され、完全な効果のためには継続投与が必要です。約21時間という比較的短い半減期およびCYP2D6代謝が、急な中止時の顕著な中止症候群に寄与します。
Brand or generic — which to choose?
For most patients, authorised generics of Paroxetine are clinically equivalent substitutes for Paxil and typically cost substantially less. The practical differences are manufacturer, excipients (rarely matters except in specific sensitivities), tablet appearance and price. The brand is preferred by some patients for personal reasons or insurance coverage; the generic is the default when cost matters.
よくある質問
Is Paxil the same as Paroxetine? ▾
Clinically yes — Paxil is the brand and Paroxetine is its active ingredient. At equivalent doses (10mg, 20mg, 30mg, 40mg) they produce the same effect. The difference is brand, manufacturer (GlaxoSmithKline) and price.
Is generic Paroxetine as effective as Paxil? ▾
Yes. Authorised generics of Paroxetine must demonstrate bioequivalence to the brand. The active substance is the same; average effect is the same. Price is usually substantially lower.
Why does Paxil cost more than generic Paroxetine? ▾
The price difference reflects originator development costs, brand recognition and competition among generic manufacturers. The molecule is identical; the cost is not.
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