Desyrel vs Trazodone: are they the same?
Desyrel is a commercial brand whose active ingredient is exactly Trazodone. This page explains what that means in practice: where they differ (brand, manufacturer, price, available strengths), why they are clinically equivalent, and when the brand or an authorised generic is the better choice.
Are they the same?
Yes — Desyrel contains Trazodone as its active ingredient. Talking about "Desyrel" in clinical terms is the same as talking about Trazodone at the dose strengths 50mg, 100mg, 150mg, 300mg. The differences from the authorised generic are brand, manufacturer (Various generics), excipients, tablet appearance and price — not the active molecule itself.
When Desyrel is used
デジレル(トラゾドン)は大うつ病性障害に承認されています。適応外使用として、不眠(現在最も多い用途)、不安を伴ううつ病、心的外傷後ストレス障害、睡眠目的でのSSRI併用に広く用いられます。現在の睡眠ガイドラインによれば、低用量のトラゾドンは慢性不眠の選択肢の一つで、特に依存懸念により標準的な睡眠薬(ゾルピデム、エスゾピクロン)が不適切な場合に用いられます。
Mechanisms compared
Because they share the same active ingredient, the mechanism is identical: トラゾドンはセロトニン拮抗・再取り込み阻害薬(SARI)に分類されます。5-HT2A受容体を遮断しセロトニン再取り込みを弱く阻害するとともに、H1ヒスタミン受容体およびα1アドレナリン受容体に対する強い拮抗作用を示します。低用量では抗ヒスタミン作用とα1遮断作用が優位となり鎮静を発現し、抗うつ作用はセロトニン作用が顕在化する高用量で必要となります。半減期5-9時間により1日1回就寝時投与に適しています。
Brand or generic — which to choose?
For most patients, authorised generics of Trazodone are clinically equivalent substitutes for Desyrel and typically cost substantially less. The practical differences are manufacturer, excipients (rarely matters except in specific sensitivities), tablet appearance and price. The brand is preferred by some patients for personal reasons or insurance coverage; the generic is the default when cost matters.
よくある質問
Is Desyrel the same as Trazodone? ▾
Clinically yes — Desyrel is the brand and Trazodone is its active ingredient. At equivalent doses (50mg, 100mg, 150mg, 300mg) they produce the same effect. The difference is brand, manufacturer (Various generics) and price.
Is generic Trazodone as effective as Desyrel? ▾
Yes. Authorised generics of Trazodone must demonstrate bioequivalence to the brand. The active substance is the same; average effect is the same. Price is usually substantially lower.
Why does Desyrel cost more than generic Trazodone? ▾
The price difference reflects originator development costs, brand recognition and competition among generic manufacturers. The molecule is identical; the cost is not.
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