Cymbalta vs Duloxetine: are they the same?
Cymbalta is a commercial brand whose active ingredient is exactly Duloxetine. This page explains what that means in practice: where they differ (brand, manufacturer, price, available strengths), why they are clinically equivalent, and when the brand or an authorised generic is the better choice.
Are they the same?
Yes — Cymbalta contains Duloxetine as its active ingredient. Talking about "Cymbalta" in clinical terms is the same as talking about Duloxetine at the dose strengths 20mg, 30mg, 60mg. The differences from the authorised generic are brand, manufacturer (Eli Lilly), excipients, tablet appearance and price — not the active molecule itself.
When Cymbalta is used
サインバルタは大うつ病性障害、全般性不安障害、糖尿病性末梢神経障害性疼痛、線維筋痛症、慢性筋骨格疼痛に承認されています。臨床ガイドラインによれば、うつ病と疼痛が共存する場合に一般に第一選択であり、気分症状にかかわらず線維筋痛症と糖尿病性神経障害の好まれる第一選択薬の一つです。
Mechanisms compared
Because they share the same active ingredient, the mechanism is identical: サインバルタはシナプスでセロトニンとノルアドレナリンの再取り込みを共に阻害します。二重モノアミン作用は4〜6週間にわたる抗うつ効果に寄与し、また脊髄の下行性疼痛調節経路を介して鎮痛効果に寄与します。気分が改善する前であっても疼痛緩和は1〜2週間以内に現れることがあります。ドーパミン効果はブプロピオンと比較して弱いです。
Brand or generic — which to choose?
For most patients, authorised generics of Duloxetine are clinically equivalent substitutes for Cymbalta and typically cost substantially less. The practical differences are manufacturer, excipients (rarely matters except in specific sensitivities), tablet appearance and price. The brand is preferred by some patients for personal reasons or insurance coverage; the generic is the default when cost matters.
よくある質問
Is Cymbalta the same as Duloxetine? ▾
Clinically yes — Cymbalta is the brand and Duloxetine is its active ingredient. At equivalent doses (20mg, 30mg, 60mg) they produce the same effect. The difference is brand, manufacturer (Eli Lilly) and price.
Is generic Duloxetine as effective as Cymbalta? ▾
Yes. Authorised generics of Duloxetine must demonstrate bioequivalence to the brand. The active substance is the same; average effect is the same. Price is usually substantially lower.
Why does Cymbalta cost more than generic Duloxetine? ▾
The price difference reflects originator development costs, brand recognition and competition among generic manufacturers. The molecule is identical; the cost is not.
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