Aygestin vs Norethindrone: are they the same?
Aygestin is a commercial brand whose active ingredient is exactly Norethindrone. This page explains what that means in practice: where they differ (brand, manufacturer, price, available strengths), why they are clinically equivalent, and when the brand or an authorised generic is the better choice.
Are they the same?
Yes — Aygestin contains Norethindrone as its active ingredient. Talking about "Aygestin" in clinical terms is the same as talking about Norethindrone at the dose strengths 5mg. The differences from the authorised generic are brand, manufacturer (Various generics), excipients, tablet appearance and price — not the active molecule itself.
When Aygestin is used
アイジェスチンは子宮内膜症関連疼痛、ホルモンバランス異常による異常子宮出血、続発性無月経に承認されています。現行の婦人科ガイドラインによれば、高用量ノルエチンドロンは合剤型ホルモン避妊薬や他のプロゲスチンと並ぶ子宮内膜症疼痛に対する第一選択の薬物治療オプションの一つです。基礎にプロゲスチン作用があるにもかかわらず本用量では避妊薬ではなく、添付文書にもアイジェスチン単独では避妊効果は保証されないと明記されています。
Mechanisms compared
Because they share the same active ingredient, the mechanism is identical: ノルエチンドロンはプロゲステロン受容体に結合し、プロゲスチン作用を発揮します：頸管粘液の濃化、LHサージの抑制、子宮内膜の薄化、子宮内膜症における内膜病変活動の抑制。また新世代プロゲスチンとは異なる弱い男性ホルモン様作用を有します。1日5mgの高用量プロゲスチン作用は子宮内膜の増殖を効果的に抑制し、このためアイジェスチンは避妊ではなく子宮内膜症や異常子宮出血に使用されます。
Brand or generic — which to choose?
For most patients, authorised generics of Norethindrone are clinically equivalent substitutes for Aygestin and typically cost substantially less. The practical differences are manufacturer, excipients (rarely matters except in specific sensitivities), tablet appearance and price. The brand is preferred by some patients for personal reasons or insurance coverage; the generic is the default when cost matters.
よくある質問
Is Aygestin the same as Norethindrone? ▾
Clinically yes — Aygestin is the brand and Norethindrone is its active ingredient. At equivalent doses (5mg) they produce the same effect. The difference is brand, manufacturer (Various generics) and price.
Is generic Norethindrone as effective as Aygestin? ▾
Yes. Authorised generics of Norethindrone must demonstrate bioequivalence to the brand. The active substance is the same; average effect is the same. Price is usually substantially lower.
Why does Aygestin cost more than generic Norethindrone? ▾
The price difference reflects originator development costs, brand recognition and competition among generic manufacturers. The molecule is identical; the cost is not.
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