Nucleoside antiviral prodrug
Who should not take Valacyclovir
A contraindication is a condition under which Valacyclovir (Valacyclovir) should not be taken because the risk outweighs the benefit. Valacyclovir has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 500mg, 1000mg dosing range.
Absolute contraindications
According to the prescribing information for Valacyclovir, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Valacyclovir can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Valacyclovir is rapidly and almost completely converted to acyclovir during first-pass intestinal and hepatic metabolism by valacyclovir hydrolase.
Frequently asked questions
Can someone with heart disease take Valacyclovir? ▾
Some forms of heart disease are absolute contraindications for Valacyclovir, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Valacyclovir use under specialist supervision. The prescribing information for Valacyclovir should be reviewed.
Is Valacyclovir safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Valacyclovir at adjusted lower 500mg, 1000mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Valacyclovir
More on Valacyclovir
- With alcoholValacyclovir and alcohol — is it safe to drink?
- With foodShould Valacyclovir be taken with food?
- Side effectsValacyclovir side effects: common, rare and warning signs
- Dosage guideValacyclovir dosage guide: how much to take and when
- OnsetHow fast does Valacyclovir start working?
- DurationHow long does Valacyclovir last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.