PDE5 inhibitor
Sildenafil Citrate with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Sildenafil Citrate (Sildenafil Citrate). Most antibiotics do not interfere meaningfully with Sildenafil Citrate at 100mg, 50mg, 25mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some PDE5 inhibitor agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Sildenafil Citrate at 100mg, 50mg, 25mg.
Practical guidance
According to the prescribing information for Sildenafil Citrate, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Sildenafil Citrate is co-administered. Adjusted 100mg, 50mg, 25mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Sildenafil Citrate during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Sildenafil Citrate is metabolised and may need a temporary 100mg, 50mg, 25mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Sildenafil Citrate regimen.
Will antibiotics make Sildenafil Citrate stop working? ▾
Most antibiotics do not affect Sildenafil Citrate efficacy. Rifampicin and a few others can lower Sildenafil Citrate levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Sildenafil Citrate
More on Sildenafil Citrate
- With alcoholSildenafil Citrate and alcohol — is it safe to drink?
- With foodShould Sildenafil Citrate be taken with food?
- Side effectsSildenafil Citrate side effects: common, rare and warning signs
- Dosage guideSildenafil Citrate dosage guide: how much to take and when
- OnsetHow fast does Sildenafil Citrate start working?
- DurationHow long does Sildenafil Citrate last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.