PDE5 inhibitor
Sildenafil Citrate drug interactions: a practical overview
Drug interactions are the single biggest cause of preventable medication problems. Sildenafil Citrate (Sildenafil Citrate) interacts to varying degrees with several classes of medication and with a smaller list of foods. This page summarises the practically important ones at 100mg, 50mg, 25mg, framed for a real-world prescription review rather than an exhaustive PDF list.
High-priority interactions for Sildenafil Citrate
For Sildenafil Citrate, the most clinically relevant interactions are typically with strong CYP3A4 inhibitors and inducers, with cardiovascular medications (notably nitrates for several PDE5 inhibitor agents), with central nervous system depressants, and with medications affecting blood pressure or heart rate. Sildenafil citrate selectively inhibits phosphodiesterase type 5 (PDE5), an enzyme that breaks down cyclic guanosine monophosphate in the corpus cavernosum.
Working with the pharmacist
A pharmacist review of all current medications is the practical safeguard against unintended interactions with Sildenafil Citrate. According to the prescribing information for Sildenafil Citrate, the full medication list — prescription, OTC, supplements and recreational substances — should be reviewed before starting and at every dose change at 100mg, 50mg, 25mg.
Frequently asked questions
What's the most important Sildenafil Citrate interaction to know? ▾
For most PDE5 inhibitor medications, the highest-priority interaction is with nitrate medications used for chest pain — this combination is often a hard contraindication. After that, strong CYP3A4 inhibitors (some antifungals, macrolides) are the next concern at routine 100mg, 50mg, 25mg doses.
Do I need to tell the pharmacist about supplements? ▾
Yes. Supplements and herbal products can interact with Sildenafil Citrate in ways that prescription drug-drug interaction databases miss. The pharmacist needs the complete picture — including supplements like St John's Wort, grapefruit-containing products and high-dose vitamins — to flag risks at 100mg, 50mg, 25mg.
Products containing Sildenafil Citrate
More on Sildenafil Citrate
- With alcoholSildenafil Citrate and alcohol — is it safe to drink?
- With foodShould Sildenafil Citrate be taken with food?
- Side effectsSildenafil Citrate side effects: common, rare and warning signs
- Dosage guideSildenafil Citrate dosage guide: how much to take and when
- OnsetHow fast does Sildenafil Citrate start working?
- DurationHow long does Sildenafil Citrate last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.