Selective estrogen receptor modulator (SERM)
Raloxifene drug interactions: a practical overview
Drug interactions are the single biggest cause of preventable medication problems. Raloxifene (Raloxifene) interacts to varying degrees with several classes of medication and with a smaller list of foods. This page summarises the practically important ones at 60mg, framed for a real-world prescription review rather than an exhaustive PDF list.
High-priority interactions for Raloxifene
For Raloxifene, the most clinically relevant interactions are typically with strong CYP3A4 inhibitors and inducers, with cardiovascular medications (notably nitrates for several Selective estrogen receptor modulator (SERM) agents), with central nervous system depressants, and with medications affecting blood pressure or heart rate. Raloxifene binds estrogen receptors and produces tissue-selective effects: estrogen-agonist activity in bone (preserving bone mineral density) and on lipid metabolism (lowering LDL cholesterol), while…
Working with the pharmacist
A pharmacist review of all current medications is the practical safeguard against unintended interactions with Raloxifene. According to the prescribing information for Raloxifene, the full medication list — prescription, OTC, supplements and recreational substances — should be reviewed before starting and at every dose change at 60mg.
Frequently asked questions
What's the most important Raloxifene interaction to know? ▾
For most Selective estrogen receptor modulator (SERM) medications, the highest-priority interaction is with nitrate medications used for chest pain — this combination is often a hard contraindication. After that, strong CYP3A4 inhibitors (some antifungals, macrolides) are the next concern at routine 60mg doses.
Do I need to tell the pharmacist about supplements? ▾
Yes. Supplements and herbal products can interact with Raloxifene in ways that prescription drug-drug interaction databases miss. The pharmacist needs the complete picture — including supplements like St John's Wort, grapefruit-containing products and high-dose vitamins — to flag risks at 60mg.
Products containing Raloxifene
More on Raloxifene
- With alcoholRaloxifene and alcohol — is it safe to drink?
- With foodShould Raloxifene be taken with food?
- Side effectsRaloxifene side effects: common, rare and warning signs
- Dosage guideRaloxifene dosage guide: how much to take and when
- OnsetHow fast does Raloxifene start working?
- DurationHow long does Raloxifene last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.