Selective estrogen receptor modulator (SERM)
Who should not take Raloxifene
A contraindication is a condition under which Raloxifene (Raloxifene) should not be taken because the risk outweighs the benefit. Raloxifene has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 60mg dosing range.
Absolute contraindications
According to the prescribing information for Raloxifene, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Raloxifene can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Raloxifene binds estrogen receptors and produces tissue-selective effects: estrogen-agonist activity in bone (preserving bone mineral density) and on lipid metabolism (lowering LDL cholesterol), while…
Frequently asked questions
Can someone with heart disease take Raloxifene? ▾
Some forms of heart disease are absolute contraindications for Raloxifene, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Raloxifene use under specialist supervision. The prescribing information for Raloxifene should be reviewed.
Is Raloxifene safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Raloxifene at adjusted lower 60mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Raloxifene
More on Raloxifene
- With alcoholRaloxifene and alcohol — is it safe to drink?
- With foodShould Raloxifene be taken with food?
- Side effectsRaloxifene side effects: common, rare and warning signs
- Dosage guideRaloxifene dosage guide: how much to take and when
- OnsetHow fast does Raloxifene start working?
- DurationHow long does Raloxifene last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.