Proton pump inhibitor
Pantoprazole with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Pantoprazole (Pantoprazole). Most antibiotics do not interfere meaningfully with Pantoprazole at 20mg, 40mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Proton pump inhibitor agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Pantoprazole at 20mg, 40mg.
Practical guidance
According to the prescribing information for Pantoprazole, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Pantoprazole is co-administered. Adjusted 20mg, 40mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Pantoprazole during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Pantoprazole is metabolised and may need a temporary 20mg, 40mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Pantoprazole regimen.
Will antibiotics make Pantoprazole stop working? ▾
Most antibiotics do not affect Pantoprazole efficacy. Rifampicin and a few others can lower Pantoprazole levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Pantoprazole
More on Pantoprazole
- With alcoholPantoprazole and alcohol — is it safe to drink?
- With foodShould Pantoprazole be taken with food?
- Side effectsPantoprazole side effects: common, rare and warning signs
- Dosage guidePantoprazole dosage guide: how much to take and when
- OnsetHow fast does Pantoprazole start working?
- DurationHow long does Pantoprazole last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.