Biguanide
Who should not take Metformin
A contraindication is a condition under which Metformin (Metformin) should not be taken because the risk outweighs the benefit. Metformin has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 500mg, 850mg, 1000mg dosing range.
Absolute contraindications
According to the prescribing information for Metformin, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Metformin can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Metformin's principal effect is to suppress hepatic glucose production by inhibiting mitochondrial complex I, which raises the cellular AMP/ATP ratio and activates AMP-activated protein kinase.
Frequently asked questions
Can someone with heart disease take Metformin? ▾
Some forms of heart disease are absolute contraindications for Metformin, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Metformin use under specialist supervision. The prescribing information for Metformin should be reviewed.
Is Metformin safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Metformin at adjusted lower 500mg, 850mg, 1000mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Metformin
More on Metformin
- With alcoholMetformin and alcohol — is it safe to drink?
- With foodShould Metformin be taken with food?
- Side effectsMetformin side effects: common, rare and warning signs
- Dosage guideMetformin dosage guide: how much to take and when
- OnsetHow fast does Metformin start working?
- DurationHow long does Metformin last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.