Gabapentinoid (alpha-2-delta ligand)
Gabapentin with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Gabapentin (Gabapentin). Most antibiotics do not interfere meaningfully with Gabapentin at 100mg, 300mg, 400mg, 600mg, 800mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Gabapentinoid (alpha-2-delta ligand) agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Gabapentin at 100mg, 300mg, 400mg, 600mg, 800mg.
Practical guidance
According to the prescribing information for Gabapentin, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Gabapentin is co-administered. Adjusted 100mg, 300mg, 400mg, 600mg, 800mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Gabapentin during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Gabapentin is metabolised and may need a temporary 100mg, 300mg, 400mg, 600mg, 800mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Gabapentin regimen.
Will antibiotics make Gabapentin stop working? ▾
Most antibiotics do not affect Gabapentin efficacy. Rifampicin and a few others can lower Gabapentin levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Gabapentin
More on Gabapentin
- With alcoholGabapentin and alcohol — is it safe to drink?
- With foodShould Gabapentin be taken with food?
- Side effectsGabapentin side effects: common, rare and warning signs
- Dosage guideGabapentin dosage guide: how much to take and when
- OnsetHow fast does Gabapentin start working?
- DurationHow long does Gabapentin last?
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