Multifunctional serotonin agonist/antagonist (HSDD)
Flibanserin drug interactions: a practical overview
Drug interactions are the single biggest cause of preventable medication problems. Flibanserin (Flibanserin) interacts to varying degrees with several classes of medication and with a smaller list of foods. This page summarises the practically important ones at 100mg, framed for a real-world prescription review rather than an exhaustive PDF list.
High-priority interactions for Flibanserin
For Flibanserin, the most clinically relevant interactions are typically with strong CYP3A4 inhibitors and inducers, with cardiovascular medications (notably nitrates for several Multifunctional serotonin agonist/antagonist (HSDD) agents), with central nervous system depressants, and with medications affecting blood pressure or heart rate. Flibanserin acts as a serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist, with additional effects on dopamine and norepinephrine signalling.
Working with the pharmacist
A pharmacist review of all current medications is the practical safeguard against unintended interactions with Flibanserin. According to the prescribing information for Flibanserin, the full medication list — prescription, OTC, supplements and recreational substances — should be reviewed before starting and at every dose change at 100mg.
Frequently asked questions
What's the most important Flibanserin interaction to know? ▾
For most Multifunctional serotonin agonist/antagonist (HSDD) medications, the highest-priority interaction is with nitrate medications used for chest pain — this combination is often a hard contraindication. After that, strong CYP3A4 inhibitors (some antifungals, macrolides) are the next concern at routine 100mg doses.
Do I need to tell the pharmacist about supplements? ▾
Yes. Supplements and herbal products can interact with Flibanserin in ways that prescription drug-drug interaction databases miss. The pharmacist needs the complete picture — including supplements like St John's Wort, grapefruit-containing products and high-dose vitamins — to flag risks at 100mg.
Products containing Flibanserin
More on Flibanserin
- With alcoholFlibanserin and alcohol — is it safe to drink?
- With foodShould Flibanserin be taken with food?
- Side effectsFlibanserin side effects: common, rare and warning signs
- Dosage guideFlibanserin dosage guide: how much to take and when
- OnsetHow fast does Flibanserin start working?
- DurationHow long does Flibanserin last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.