Non-benzodiazepine hypnotic (Z-drug)
Who should not take Eszopiclone
A contraindication is a condition under which Eszopiclone (Eszopiclone) should not be taken because the risk outweighs the benefit. Eszopiclone has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 1mg, 2mg, 3mg dosing range.
Absolute contraindications
According to the prescribing information for Eszopiclone, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Eszopiclone can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Eszopiclone is a positive allosteric modulator of the GABA-A receptor at a site close to the benzodiazepine binding site.
Frequently asked questions
Can someone with heart disease take Eszopiclone? ▾
Some forms of heart disease are absolute contraindications for Eszopiclone, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Eszopiclone use under specialist supervision. The prescribing information for Eszopiclone should be reviewed.
Is Eszopiclone safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Eszopiclone at adjusted lower 1mg, 2mg, 3mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Eszopiclone
More on Eszopiclone
- With alcoholEszopiclone and alcohol — is it safe to drink?
- With foodShould Eszopiclone be taken with food?
- Side effectsEszopiclone side effects: common, rare and warning signs
- Dosage guideEszopiclone dosage guide: how much to take and when
- OnsetHow fast does Eszopiclone start working?
- DurationHow long does Eszopiclone last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.