Dual 5α-reductase inhibitor (type 1 and type 2)
Who should not take Dutasteride
A contraindication is a condition under which Dutasteride (Dutasteride) should not be taken because the risk outweighs the benefit. Dutasteride has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 0.5mg dosing range.
Absolute contraindications
According to the prescribing information for Dutasteride, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Dutasteride can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Dutasteride irreversibly inhibits both isoenzymes of 5α-reductase, the enzyme that converts testosterone to dihydrotestosterone (DHT).
Frequently asked questions
Can someone with heart disease take Dutasteride? ▾
Some forms of heart disease are absolute contraindications for Dutasteride, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Dutasteride use under specialist supervision. The prescribing information for Dutasteride should be reviewed.
Is Dutasteride safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Dutasteride at adjusted lower 0.5mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Dutasteride
More on Dutasteride
- With alcoholDutasteride and alcohol — is it safe to drink?
- With foodShould Dutasteride be taken with food?
- Side effectsDutasteride side effects: common, rare and warning signs
- Dosage guideDutasteride dosage guide: how much to take and when
- OnsetHow fast does Dutasteride start working?
- DurationHow long does Dutasteride last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.