Progestogen with anti-mineralocorticoid and anti-androgen activity
Drospirenone with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Drospirenone (Drospirenone). Most antibiotics do not interfere meaningfully with Drospirenone at 3mg / 0.03mg, 3mg/0.02mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Progestogen with anti-mineralocorticoid and anti-androgen activity agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Drospirenone at 3mg / 0.03mg, 3mg/0.02mg.
Practical guidance
According to the prescribing information for Drospirenone, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Drospirenone is co-administered. Adjusted 3mg / 0.03mg, 3mg/0.02mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Drospirenone during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Drospirenone is metabolised and may need a temporary 3mg / 0.03mg, 3mg/0.02mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Drospirenone regimen.
Will antibiotics make Drospirenone stop working? ▾
Most antibiotics do not affect Drospirenone efficacy. Rifampicin and a few others can lower Drospirenone levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Drospirenone
More on Drospirenone
- With alcoholDrospirenone and alcohol — is it safe to drink?
- With foodShould Drospirenone be taken with food?
- Side effectsDrospirenone side effects: common, rare and warning signs
- Dosage guideDrospirenone dosage guide: how much to take and when
- OnsetHow fast does Drospirenone start working?
- DurationHow long does Drospirenone last?
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