Selective estrogen receptor modulator (ovulation induction)
Clomiphene drug interactions: a practical overview
Drug interactions are the single biggest cause of preventable medication problems. Clomiphene (Clomiphene) interacts to varying degrees with several classes of medication and with a smaller list of foods. This page summarises the practically important ones at 50mg, framed for a real-world prescription review rather than an exhaustive PDF list.
High-priority interactions for Clomiphene
For Clomiphene, the most clinically relevant interactions are typically with strong CYP3A4 inhibitors and inducers, with cardiovascular medications (notably nitrates for several Selective estrogen receptor modulator (ovulation induction) agents), with central nervous system depressants, and with medications affecting blood pressure or heart rate. Clomiphene acts as a competitive antagonist of estrogen receptors at the hypothalamus, blocking the negative feedback that estrogen normally exerts on hypothalamic gonadotropin-releasing hormone produ…
Working with the pharmacist
A pharmacist review of all current medications is the practical safeguard against unintended interactions with Clomiphene. According to the prescribing information for Clomiphene, the full medication list — prescription, OTC, supplements and recreational substances — should be reviewed before starting and at every dose change at 50mg.
Frequently asked questions
What's the most important Clomiphene interaction to know? ▾
For most Selective estrogen receptor modulator (ovulation induction) medications, the highest-priority interaction is with nitrate medications used for chest pain — this combination is often a hard contraindication. After that, strong CYP3A4 inhibitors (some antifungals, macrolides) are the next concern at routine 50mg doses.
Do I need to tell the pharmacist about supplements? ▾
Yes. Supplements and herbal products can interact with Clomiphene in ways that prescription drug-drug interaction databases miss. The pharmacist needs the complete picture — including supplements like St John's Wort, grapefruit-containing products and high-dose vitamins — to flag risks at 50mg.
Products containing Clomiphene
More on Clomiphene
- With alcoholClomiphene and alcohol — is it safe to drink?
- With foodShould Clomiphene be taken with food?
- Side effectsClomiphene side effects: common, rare and warning signs
- Dosage guideClomiphene dosage guide: how much to take and when
- OnsetHow fast does Clomiphene start working?
- DurationHow long does Clomiphene last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.