Thiazide-like diuretic
Chlorthalidone with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Chlorthalidone (Chlorthalidone). Most antibiotics do not interfere meaningfully with Chlorthalidone at 15mg, 25mg, 50mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Thiazide-like diuretic agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Chlorthalidone at 15mg, 25mg, 50mg.
Practical guidance
According to the prescribing information for Chlorthalidone, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Chlorthalidone is co-administered. Adjusted 15mg, 25mg, 50mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Chlorthalidone during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Chlorthalidone is metabolised and may need a temporary 15mg, 25mg, 50mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Chlorthalidone regimen.
Will antibiotics make Chlorthalidone stop working? ▾
Most antibiotics do not affect Chlorthalidone efficacy. Rifampicin and a few others can lower Chlorthalidone levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Chlorthalidone
More on Chlorthalidone
- With alcoholChlorthalidone and alcohol — is it safe to drink?
- With foodShould Chlorthalidone be taken with food?
- Side effectsChlorthalidone side effects: common, rare and warning signs
- Dosage guideChlorthalidone dosage guide: how much to take and when
- OnsetHow fast does Chlorthalidone start working?
- DurationHow long does Chlorthalidone last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.