COX-2 selective NSAID
Celecoxib with antidepressants: interactions
Many adults take an antidepressant for mood, anxiety or chronic pain. The combination with Celecoxib (Celecoxib) is common and, for most antidepressant classes, well tolerated. A few specific combinations require attention because of additive effects or shared metabolic pathways.
Antidepressant interaction landscape
SSRIs, SNRIs, TCAs, MAOIs and atypical antidepressants each interact differently. SSRIs are the most commonly co-prescribed and usually have minor or no clinically meaningful interaction with Celecoxib at 50mg, 100mg, 200mg, 400mg. MAOIs require special caution with many medications. Tricyclics can amplify cardiovascular and sedative effects of some COX-2 selective NSAID agents.
Practical guidance
According to the prescribing information for Celecoxib, any change in antidepressant therapy should be reviewed alongside Celecoxib dosing. Switching antidepressants — particularly to or from MAOIs — usually requires a washout period before resuming Celecoxib at the standard 50mg, 100mg, 200mg, 400mg schedule.
Frequently asked questions
Can I take Celecoxib on an SSRI? ▾
For most SSRIs and most COX-2 selective NSAID agents, the combination is acceptable with normal monitoring. A few combinations require dose adjustment or alternative selection. The prescriber confirms based on the specific antidepressant and the active ingredient Celecoxib.
Are there antidepressants to avoid with Celecoxib? ▾
MAOIs are the antidepressant class most often flagged for caution with many medications. Other interactions depend on Celecoxib and the specific antidepressant; a pharmacist review is the practical safeguard at 50mg, 100mg, 200mg, 400mg.
Products containing Celecoxib
More on Celecoxib
- With alcoholCelecoxib and alcohol — is it safe to drink?
- With foodShould Celecoxib be taken with food?
- Side effectsCelecoxib side effects: common, rare and warning signs
- Dosage guideCelecoxib dosage guide: how much to take and when
- OnsetHow fast does Celecoxib start working?
- DurationHow long does Celecoxib last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.