Prostaglandin E1 (PGE1)
Who should not take Alprostadil
A contraindication is a condition under which Alprostadil (Alprostadil) should not be taken because the risk outweighs the benefit. Alprostadil has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 10mcg, 20mcg, 40mcg dosing range.
Absolute contraindications
According to the prescribing information for Alprostadil, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Alprostadil can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Alprostadil binds prostaglandin E receptors on smooth muscle of the corpus cavernosum, triggering cAMP-mediated relaxation of cavernosal smooth muscle independent of the nitric oxide pathway used by P…
Frequently asked questions
Can someone with heart disease take Alprostadil? ▾
Some forms of heart disease are absolute contraindications for Alprostadil, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Alprostadil use under specialist supervision. The prescribing information for Alprostadil should be reviewed.
Is Alprostadil safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Alprostadil at adjusted lower 10mcg, 20mcg, 40mcg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Alprostadil
More on Alprostadil
- With alcoholAlprostadil and alcohol — is it safe to drink?
- With foodShould Alprostadil be taken with food?
- Side effectsAlprostadil side effects: common, rare and warning signs
- Dosage guideAlprostadil dosage guide: how much to take and when
- OnsetHow fast does Alprostadil start working?
- DurationHow long does Alprostadil last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.