DPP-4 inhibitor
Sitagliptin in the United States: prescription, brands, pricing
This page summarises the situation of Sitagliptin in the United States under FDA (Food and Drug Administration): prescription status, available brands and generics, pharmacy dispensing, and online options in USD. Sitagliptin belongs to the DPP-4 inhibitor class.
- Regulator
- FDA (Food and Drug Administration)
- Currency
- USD
About Sitagliptin
Sitagliptin is approved in adults with type 2 diabetes mellitus, alone or in combination with other antidiabetic agents, to improve glycaemic control. In the US, most prescription medications require a written or e-prescription from a licensed prescriber. A handful of formerly-prescription medications have moved to OTC after FDA review.
Mechanism and action
Sitagliptin reversibly inhibits DPP-4, the serine protease responsible for rapid degradation of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).
Brands and generics in the United States
In the United States, Sitagliptin is typically dispensed as one internationally recognised brand along with their corresponding authorised generics. US pharmacies — both chain (CVS, Walgreens, Walmart) and independent — dispense Rx medications under state pharmacy board oversight. Pharmacist consultation is encouraged at pickup. Brand-to-generic substitution is decided by the pharmacist under local FDA (Food and Drug Administration) equivalence rules, and the price difference in USD is usually substantial.
Online and tele-prescribing access
Online prescription fulfilment in the US is well-regulated through state-licensed mail-order and tele-prescribing services. Importing prescription medication for personal use is restricted under federal law. For Sitagliptin specifically, the legal online options in the United States depend on its Rx-or-OTC classification under FDA (Food and Drug Administration).
Frequently asked questions
Is Sitagliptin available in the United States? ▾
Yes — Sitagliptin and its brands are available in the United States through pharmacies authorised by FDA (Food and Drug Administration), in various strengths depending on the commercial product. Authorised generics offer a lower-cost alternative with the same active substance.
Do I need a prescription for Sitagliptin in the United States? ▾
In the US, most prescription medications require a written or e-prescription from a licensed prescriber. A handful of formerly-prescription medications have moved to OTC after FDA review. The exact status of Sitagliptin (Rx or OTC) is determined by FDA (Food and Drug Administration); most active ingredients in the DPP-4 inhibitor class require prescription, although there are exceptions by country and formulation.
How much does Sitagliptin cost in the United States? ▾
The price in USD depends on the manufacturer (brand vs authorised generic), the strength and the pack size. Generics are typically substantially cheaper than brands and serve as the economic reference for ongoing use.
Products with Sitagliptin in the United States
Sitagliptin in other countries
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.