Zithromax with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Zithromax (Azithromycin). Most antibiotics do not interfere meaningfully with Azithromycin at 250mg, 500mg, 600mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Antibiotics agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Azithromycin at 250mg, 500mg, 600mg.
Practical guidance
According to the prescribing information for Azithromycin, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Zithromax is co-administered. Adjusted 250mg, 500mg, 600mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Zithromax during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Azithromycin is metabolised and may need a temporary 250mg, 500mg, 600mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Zithromax regimen.
Will antibiotics make Zithromax stop working? ▾
Most antibiotics do not affect Zithromax efficacy. Rifampicin and a few others can lower Azithromycin levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
More on Zithromax
- With alcoholZithromax and alcohol — is it safe to drink?
- With foodShould Zithromax be taken with food?
- Side effectsZithromax side effects: common, rare and warning signs
- Dosage guideZithromax dosage guide: how much to take and when
- OnsetHow fast does Zithromax start working?
- DurationHow long does Zithromax last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.