Stendra with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Stendra (Avanafil). Most antibiotics do not interfere meaningfully with Avanafil at 50mg, 100mg, 200mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Erectile Dysfunction (ED) agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Avanafil at 50mg, 100mg, 200mg.
Practical guidance
According to the prescribing information for Avanafil, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Stendra is co-administered. Adjusted 50mg, 100mg, 200mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Stendra during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Avanafil is metabolised and may need a temporary 50mg, 100mg, 200mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Stendra regimen.
Will antibiotics make Stendra stop working? ▾
Most antibiotics do not affect Stendra efficacy. Rifampicin and a few others can lower Avanafil levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
More on Stendra
- With alcoholStendra and alcohol — is it safe to drink?
- With foodShould Stendra be taken with food?
- Side effectsStendra side effects: common, rare and warning signs
- Dosage guideStendra dosage guide: how much to take and when
- OnsetHow fast does Stendra start working?
- DurationHow long does Stendra last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.