Spironolactone 100mg

Forms and dosages

Spironolactone is supplied as round, film-coated tablets in 25mg, 50mg and 100mg strengths. Dosing varies markedly by indication: heart failure starts at 12.5–25mg daily and rarely exceeds 50mg; primary hyperaldosteronism may use 100–400mg daily; dermatological use in women is typically 50–200mg daily. Tablets can be taken with or without food, although food slightly improves absorption.

Indications

Spironolactone is approved for heart failure with reduced ejection fraction, primary hyperaldosteronism, resistant hypertension, oedema in cirrhosis or nephrotic syndrome, and certain potassium-loss states. Off-label uses include female pattern hair loss, hirsutism, polycystic ovary syndrome and acne in women. According to clinical guidelines, it is a first-line add-on in heart failure and a strong third-agent in resistant hypertension.