Who should not take Spironolactone
A contraindication is a condition under which Spironolactone (Spironolactone) should not be taken because the risk outweighs the benefit. Spironolactone has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 25mg, 50mg, 100mg dosing range.
Absolute contraindications
According to the prescribing information for Spironolactone, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Spironolactone can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Spironolactone competitively blocks the aldosterone (mineralocorticoid) receptor in the distal tubule, reducing sodium reabsorption and potassium excretion.
Frequently asked questions
Can someone with heart disease take Spironolactone? ▾
Some forms of heart disease are absolute contraindications for Spironolactone, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Spironolactone use under specialist supervision. The prescribing information for Spironolactone should be reviewed.
Is Spironolactone safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Spironolactone at adjusted lower 25mg, 50mg, 100mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
More on Spironolactone
- With alcoholSpironolactone and alcohol — is it safe to drink?
- With foodShould Spironolactone be taken with food?
- Side effectsSpironolactone side effects: common, rare and warning signs
- Dosage guideSpironolactone dosage guide: how much to take and when
- OnsetHow fast does Spironolactone start working?
- DurationHow long does Spironolactone last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.