Restoril with statins (atorvastatin, rosuvastatin, simvastatin)
Statins are among the most widely prescribed chronic medications, often used alongside many other agents including Restoril (Temazepam). The combination at 7.5mg, 15mg, 22.5mg, 30mg is generally safe, but a small number of statin-specific interactions matter — particularly for simvastatin, which shares CYP3A4 metabolism with several common medications.
How Restoril interacts with statins
Statins differ in their metabolic pathways: simvastatin and atorvastatin go through CYP3A4 most heavily; rosuvastatin and pravastatin take other routes and have fewer drug interactions. If Temazepam acts on CYP3A4, the combination with simvastatin or atorvastatin can raise statin levels and increase muscle-related side effects. Temazepam binds the benzodiazepine site of the GABA-A receptor and allosterically enhances inhibitory chloride conductance.
Practical guidance
According to the prescribing information for Temazepam, anyone on a statin should mention it before starting Restoril at 7.5mg, 15mg, 22.5mg, 30mg. The prescriber may switch the statin (e.g. from simvastatin to rosuvastatin) or adjust the statin dose during Restoril use. Persistent muscle pain, weakness or dark urine on the combination warrants prompt evaluation.
Frequently asked questions
Can I take Restoril with my statin? ▾
For most users at 7.5mg, 15mg, 22.5mg, 30mg, yes — particularly with rosuvastatin or pravastatin which have minimal interactions with Temazepam. Simvastatin and atorvastatin combinations may need a dose review by the prescriber to avoid amplified statin effects.
Will Restoril cause muscle pain with my statin? ▾
Muscle pain is the most common statin side effect and can be amplified when combined with medications that raise statin plasma levels. Persistent or new muscle pain on Restoril at 7.5mg, 15mg, 22.5mg, 30mg should be reported promptly so the prescriber can review the combination.
More on Restoril
- With alcoholRestoril and alcohol — is it safe to drink?
- With foodShould Restoril be taken with food?
- Side effectsRestoril side effects: common, rare and warning signs
- Dosage guideRestoril dosage guide: how much to take and when
- OnsetHow fast does Restoril start working?
- DurationHow long does Restoril last?
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