Lunesta and changes in taste or smell
Changes in taste (dysgeusia) or smell (parosmia, anosmia) are an under-recognised side effect category. Some medications produce a metallic taste, a dulling of flavours, or unusual smell perception. Whether Lunesta (Eszopiclone) at 1mg, 2mg, 3mg causes these changes depends on Eszopiclone; the experience is usually benign but can affect appetite and quality of life.
Why taste and smell change on Lunesta
Taste and smell perception relies on receptors in the tongue and nose that are sensitive to systemic medications. Eszopiclone can affect taste through several mechanisms: alteration of saliva composition, direct receptor interference, secretion in saliva of medication metabolites, or changes in zinc handling. Eszopiclone is a positive allosteric modulator of the GABA-A receptor at a site close to the benzodiazepine binding site.
When changes need attention
Mild metallic taste or dulled flavours in the first weeks of Lunesta at 1mg, 2mg, 3mg are common and often resolve as the body adjusts. Persistent severe loss of taste or smell, sudden onset, or interference with eating warrants prescriber review — both because the medication may need adjustment and because other causes (zinc deficiency, sinus disease) should be excluded.
Frequently asked questions
Can Lunesta change my taste or smell? ▾
Yes, some users report taste or smell changes on Lunesta at 1mg, 2mg, 3mg — typically a metallic or dulled-flavour sensation that develops in the first weeks. The prescribing information for Eszopiclone lists frequency in clinical trials. Most cases are mild and resolve.
Will my taste come back when I stop Lunesta? ▾
For most users, taste changes attributable to Lunesta resolve within weeks of stopping the medication. Persistent loss after stopping, or severe loss while on therapy, deserves a clinical evaluation since other causes may be involved.
More on Lunesta
- With alcoholLunesta and alcohol — is it safe to drink?
- With foodShould Lunesta be taken with food?
- Side effectsLunesta side effects: common, rare and warning signs
- Dosage guideLunesta dosage guide: how much to take and when
- OnsetHow fast does Lunesta start working?
- DurationHow long does Lunesta last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.