Livial with kidney impairment: dosing and safety
Kidney function affects how the body clears Livial (Tibolone) and many of its metabolites. For people with chronic kidney disease, dialysis, or even mild renal impairment from age or comorbidities, the standard 2.5mg dose may need adjustment. This page summarises the practical principles for Livial in renal impairment.
Why renal function matters for Livial
A meaningful fraction of Tibolone or its active metabolites is cleared by the kidneys for many medications. Reduced eGFR slows clearance, raises plasma concentrations and prolongs effect. Tibolone in Livial is rapidly converted to three active metabolites with tissue-selective activity. The prescribing information for Tibolone usually specifies dose adjustments by eGFR threshold (e.g. 30–60 vs <30 mL/min/1.73m²).
Practical guidance
According to the prescribing information, baseline kidney function should be checked before starting Livial and periodically during treatment. People on dialysis need specialist input on dose timing relative to dialysis. Acute kidney injury — from dehydration, infection or other medications — can shift Livial effects unpredictably and may warrant a temporary hold at 2.5mg.
Frequently asked questions
Is Livial safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Livial at adjusted lower 2.5mg doses with monitoring. Severe impairment (eGFR <30) often requires substantial reduction or alternative therapy. The prescriber decides based on lab results and the indication.
Do I need lab tests on Livial if I have kidney disease? ▾
Yes — periodic eGFR and electrolyte monitoring is the standard practice for Livial in chronic kidney disease. Frequency depends on the severity of impairment and on Tibolone-specific risks. The prescriber sets the schedule.
More on Livial
- With alcoholLivial and alcohol — is it safe to drink?
- With foodShould Livial be taken with food?
- Side effectsLivial side effects: common, rare and warning signs
- Dosage guideLivial dosage guide: how much to take and when
- OnsetHow fast does Livial start working?
- DurationHow long does Livial last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.